Research Article
D. Prakash Chandra, IJPRBS, 2018; Volume 7(6): 1-18

FORMULATION AND EVALUATION OF DILTIAZEM HCL SUSTAINED RELEASE TABLETS BY USING DIRECT COMPRESSION METHOD.

D. PRAKASH CHANDRA, R. ARCHANA, S. ASMA, F. JABEEN, S. PARVEEN

http://dx.doi.org/10.32395/IJPRS.V7.I6.00001

Abstract:

Diltiazem is a calcium channel blocker is used to treat high blood pressure and to control angina (chest pain). Its main use is to relaxing the muscles of heart and tissues. The development of Diltiazem tablets of matrix by applying various polymers in various formulations in different compositions. First undergo to check the drug characteristic that is the bioavailability of drug is 50%. The selected polymers incorporating into the sustained preparation of tablets of Diltiazem. The HPMC100M, ethyl cellulose is used for development by using direct compression method. The talc is used as glident and Mg.stearate used as lubricant. After formulation development undergo for evaluation parameters such as weight variation, thickness, hardness, drug content, disintegration, drug release studies. The optimised formulation under go for mathematical modelling .It fallows the Zero order and Higuchi equation. The optimised formulation undergo for stability studies for longer period of time for 3months .In stability studies performs the drug release studies and drug content studies. There no degradation between in formulation after 3months.

Keyword:

Diltiazem, Calcium channel blocker, direct compression method, Tablets